RecruitingPhase 2NCT05359263

Effects of Dapagliflozin on EChOcardiographic Measures of CarDiac StructurE and Function in Patients with CKD

A 6-Month, Randomized, Double-Blind Study to Evaluate the Effect of Dapagliflozin on EChOcardiographic Measures of CarDiac StructurE and Function in Patients with Chronic Kidney Disease


Sponsor

Tor Biering-Sørensen

Enrollment

222 participants

Start Date

Jun 8, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to investigate the effects of dapagliflozin on echocardiographic measures of cardiac structure and function in patients with chronic kidney disease.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is examining whether dapagliflozin — a diabetes and kidney protection medication — improves the structure and function of the heart in people with chronic kidney disease (CKD). **You may be eligible if...** - You are 18 or older - You have chronic kidney disease with reduced kidney function (specific eGFR ranges) or with significant protein in your urine - You have been on a stable dose of a blood pressure/kidney-protective medication (ACE inhibitor or ARB) for at least 4 weeks **You may NOT be eligible if...** - You are already taking a medication in the same class as dapagliflozin (SGLT2 inhibitors) - You have type 1 diabetes - You have severe heart failure (certain classifications) - Your kidney function is below the required minimum - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDapagliflozin 10 mg

The intervention arm consists of dapagliflozin 10 mg orally once daily

DRUGPlacebo

The comparator arm consists of placebo orally once daily


Locations(1)

Gentofte Hospital

Copenhagen, Denmark

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NCT05359263


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