LYMPHA Procedure for the Prevention of Lymphedema After Axillary Lymphadenectomy

This study is testing a surgical procedure called LYMPHA (Lymphatic Microsurgical Preventive Healing Approach) to prevent lymphedema (arm swelling from blocked lymph vessels) in breast cancer patients who need lymph node removal from the armpit. The procedure reconnects lymphatic vessels during breast cancer surgery to reduce the risk of lymphedema developing later. **You may be eligible if...** - You are 18–75 years old - You are having breast cancer surgery that includes removal of lymph nodes from the armpit - You do not currently have lymphedema in the arm - You have no distant cancer spread detected before surgery **You may NOT be eligible if...** - You already have lymphedema in the affected arm - You have had radiation to the armpit area before this surgery - You are allergic to pig collagen or ICG dye (used in the procedure) - You are pregnant or nursing - You have severe kidney or liver disease - Your life expectancy is less than 2 years - You have a condition that would cause arm swelling for other reasons Talk to your doctor to see if this trial is right for you.