Lymphedema Clinical Trials

42 recruiting

Lymphedema Trials at a Glance

78 actively recruiting trials for lymphedema are listed on ClinicalTrialsFinder across 6 cities in 24 countries. The largest study group is Not Applicable with 48 trials, with the heaviest enrollment activity in New York, Leuven, and Houston. Lead sponsors running lymphedema studies include Universitaire Ziekenhuizen KU Leuven, M.D. Anderson Cancer Center, and Abramson Cancer Center at Penn Medicine.

Browse lymphedema trials by phase

Treatments under study

About Lymphedema Clinical Trials

Looking for clinical trials for Lymphedema? There are currently 42 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Lymphedema trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Lymphedema clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 78 trials

Recruiting
Not Applicable

ILR to Prevent BRCL_MCC 23608

Breast Cancer Lymphedema
University of South Florida98 enrolled3 locationsNCT07127003
Recruiting

Deep Learning for Musculoskeletal Complications in Breast Cancer

Osteoporosis SecondaryPostmastectomy Lymphedema SyndromeBreast Cancer Surgery Pain+2 more
Ankara Etlik City Hospital133 enrolled1 locationNCT07236658
Recruiting
Not Applicable

CONNECT: A Multi-Cohort, Prospective Investigation of the Symani® Surgical System

LymphedemaFree Tissue TransferMicrosurgery
MMI (Medical Microinstruments, Inc.)180 enrolled1 locationNCT06866197
Recruiting
Not Applicable

The Effect of Manual Lymph Drainage Applied as an Adjunct to Compression Therapy on Edema Lower Extremity Lymphedema:

Lower Extremity Lymphedema
Abant Izzet Baysal University30 enrolled1 locationNCT06750679
Recruiting
Not Applicable

Investigation of the Effects of Complex Decongestive Physiotherapy on Sleep Quality and Quality of Life in Women With Breast Cancer Related Lymphedema

Breast Cancer Related Lymphedema
Abant Izzet Baysal University31 enrolled2 locationsNCT06697158
Recruiting
Not Applicable

Clinical Study to Evaluate the Effectiveness and Health Economics of a Novel Portable Non-Pneumatic Active Compression Device (NPCD) for Lymphedema/Phlebolymphedema

LymphedemaPhlebolymphedema
Koya Medical, Inc.100 enrolled1 locationNCT06418282
Recruiting
Not Applicable

Effects of Extracorporeal Shock Wave Therapy and Pulse Electromagnetic Field Therapy on Lymphoedema

Lymphedema
Zheng-Yu Hoe, MD., PhD.90 enrolled1 locationNCT06041958
Recruiting
Not Applicable

Impact of Photobiomodulation (PBM) on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer Patients

Head and Neck CancerRadiation FibrosisRadiation Lymphedema
NYU Langone Health60 enrolled1 locationNCT06708754
Recruiting

Multimodal Ultrasound for Differentiating Lymphedema and Lipedema

LymphedemaLipedema
Kayseri City Hospital75 enrolled1 locationNCT07489248
Recruiting
Not Applicable

Impact of Virtual Reality (VR) Based Exercises on Lower Limb Lymphedema Outcomes (LELO)

LymphedemaGait Dysfunction
Gaziler Physical Medicine and Rehabilitation Education and Research Hospital40 enrolled2 locationsNCT07472543
Recruiting

Longitudinal Body Composition Assessment in Breast Cancer Patients

Breast NeoplasmsBody CompositionSarcopenia+2 more
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation100 enrolled1 locationNCT07472803
Recruiting
Not Applicable

Investigation of the Effectiveness of Progressive Resistance Exercise Training in the Management of Lymphedema.

Breast CancerLymphedema
Uskudar University50 enrolled1 locationNCT07448467
Recruiting

Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study

Arteriovenous MalformationsVascular AnomalyOsler Rendu Disease+3 more
Hospices Civils de Lyon400 enrolled36 locationsNCT04194619
Recruiting
Not Applicable

Pectoral Nerve Block Versus Paravertebral Block In The Incidence of Chronic Pain After Mastectomy:

Mastectomy; LymphedemaChronic PainParavertebral Block+1 more
Assiut University90 enrolled1 locationNCT06082206
Recruiting

A Post-market, Real-world Experience: Expanding Access to Care by Incorporating the Symani® Surgical System and Enabling Surgeons

LymphedemaAnastomosis, SurgicalFree Tissue Transfer+2 more
MMI (Medical Microinstruments, Inc.)455 enrolled4 locationsNCT06725030
Recruiting
Phase 2

Lymphedema Prevention Through Immediate Lymphatic Reconstruction (LILY) Trial.

Lymphedema
M.D. Anderson Cancer Center50 enrolled1 locationNCT06989099
Recruiting
Not Applicable

Aerobic Training in Lower Extremity Lymphedema

LymphedemaLymphedema Lower Extremity
Bezmialem Vakif University24 enrolled1 locationNCT07414615
Recruiting
Phase 2

Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)

LymphedemaFibrosis
M.D. Anderson Cancer Center295 enrolled1 locationNCT06494111
Recruiting
Phase 2

Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

LymphedemaFibrosisHead &Amp; Neck Cancer+1 more
M.D. Anderson Cancer Center250 enrolled1 locationNCT06912763
Recruiting
Not Applicable

Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema

Head and Neck CancerLymphedema of the Head and Neck
Abramson Cancer Center at Penn Medicine150 enrolled2 locationsNCT06837480