Durable Effect of Imeglimin on the Glycemic Control in Patients With Type 2 Diabetes Mellitus

This study is testing the long-term effects of a diabetes drug called imeglimin (combined with metformin or another diabetes drug) on blood sugar control in people with type 2 diabetes in Japan. Researchers want to see if imeglimin keeps working well over time. **You may be eligible if...** - You are 20 or older and have type 2 diabetes - Your HbA1c (blood sugar average) is between 7.0% and 9.0% - You are currently managing your diabetes with diet/exercise alone, or with just one oral diabetes medication that can be stopped temporarily before the study **You may NOT be eligible if...** - You have type 1 diabetes - You have taken 2 or more oral diabetes medications within the past 12 weeks - You have taken a GLP-1 receptor agonist injection within the past year - You have severe obesity (BMI above 35) - You have severe heart failure (NYHA class III or IV) - You are pregnant or planning to become pregnant - You have severe kidney disease (eGFR below 45) - You have severe liver disease - You are currently being treated for cancer or have been in the past 5 years Talk to your doctor to see if this trial is right for you.