Neoadjuvant Chemotherapy Followed by Chemoradiation Versus Chemoradiation for Stage IIIC Cervical Cancer Patients: A Randomized Phase III Trial

This randomized trial is comparing two treatment approaches for stage IIIC cervical cancer: chemotherapy given before chemoradiation (combined chemo + radiation) versus chemoradiation alone. Researchers want to find out if starting with chemotherapy first improves survival. **You may be eligible if...** - You are 18–70 years old - You have been newly diagnosed with stage IIIC cervical cancer (confirmed by biopsy as squamous cell, adenocarcinoma, or adenosquamous type) - Your tumor is larger than 4 cm or you have lymph node involvement greater than 2 cm - You are in reasonably good health (ECOG 0–2) - Your organ function is adequate **You may NOT be eligible if...** - You have previously been treated for cervical cancer - You have another type of cancer - You are not at the initial diagnosis stage Talk to your doctor to see if this trial is right for you.