AK104 With Chemotherapy as Neoadjuvant and Adjuvant Therapy for Resectable Non-small Cell Lung Cancer
A Single-Arm, Phase II Study of AK104 With Chemotherapy as Neoadjuvant and Adjuvant Therapy for Resectable Non-small Cell Lung Cancer
Henan Cancer Hospital
43 participants
Jul 26, 2022
INTERVENTIONAL
Conditions
Summary
AK104, a tetravalent bispecific antibody targeting PD-1 and CTLA-4, is designed to retain the efficacy benefit of combination of PD-1 and CTLA-4 and improve on the safety profile of the combination therapy. The aim of this study is to evaluate the efficacy and safety of AK104 with chemotherapy as neoadjuvant and adjuvant therapy for patients with resectable stage II-IIIA NSCLC.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
10 mg/kg via intravenous infusion on Day 1 of each 21-day cycle.
260mg/m\^2 via intravenous infusion on Day 1 of each 21-day cycle.
AUC 5 mg/mL/min via intravenous infusion on Day 1 of each 21-day cycle.
Locations(1)
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NCT05377658