Fecal Immunochemical Test for Post-polypectomy Surveillance to Reduce Unnecessary eNdoscopy
Fecal Immunochemical Test for Post-polypectomy Surveillance to Reduce Unnecessary eNdoscopy (FIT2RUN Study)
University of Calgary
3,000 participants
Apr 15, 2022
OBSERVATIONAL
Conditions
Summary
This is an observational study in a clinical setting to estimate the prevalence of advanced colorectal neoplasia (ACN) at colonoscopy in those with a history of low or high risk polyps or a family history of CRC/polyps and to verify the test performance characteristics of FIT in these populations. Using this information, a risk prediction model will be developed to help guide the choice between FIT and colonoscopy in the ongoing surveillance or screening of patients.
Eligibility
Inclusion Criteria5
- Men or women age ≤ 74 years of age.
- At least one risk factor for CRC that would generally lead to colonoscopy screening:
- Personal history of low risk polyps
- Personal history of high risk polyps
- Family history of CRC or polyps
Exclusion Criteria6
- Known acromegaly, cystic fibrosis or high risk profession (firefighter)
- Referred for colonoscopy due to a positive fecal immunochemical test or CT colonography
- Known or suspected gene carrier for a familial cancer syndrome.
- Does not meet medical criteria for colonoscopy at the CCSC.
- Colonoscopy within the previous 30 months
- Unable to provide written informed consent or complete questionnaires due to language barrier or other reasons.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05396560