SOTO: Treatment Sensitivity of Organoids to Predict Treatment Outcome

This study is growing small copies of patients' tumors in the lab (called organoids) to test which treatments are most likely to work — potentially helping doctors choose the best therapy for each individual person with head and neck cancer. **You may be eligible if...** - You are over 18 years old - You have been diagnosed with squamous cell carcinoma of the head and neck (including oral cavity, throat, sinuses, voice box, or lower throat) - You are receiving treatment with either surgery or radiation, or have recurring or metastatic disease **You may NOT be eligible if...** - You are unable to give informed consent (for example, due to a cognitive or intellectual disability) - You are under 18 years old Talk to your doctor to see if this trial is right for you.