RecruitingNCT05400499

Deep Brain Stimulation for Visuomotor Function in Parkinson's Disease

Deep Brain Stimulation for Visuomotor Function in Parkinsons Disease


Sponsor

VA Office of Research and Development

Enrollment

40 participants

Start Date

Oct 4, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

Inability to align and refocus the eyes on the objects at different depths, i.e., vergence impairment, frequently affects the quality of life in patients with Parkinson's disease. Our study aims to understand the location-specific effects of subthalamic region deep brain stimulation on vergence by integrating the patient-specific deep brain stimulation models and high-resolution eye-tracking measures. The knowledge gained will allow us to find the most beneficial stimulation location and parameters for improving binocular coordination and vergence while preserving the ability to treat motor symptoms in Parkinson's disease.


Eligibility

Plain Language Summary

Simplified for easier understanding

This study is investigating how deep brain stimulation (DBS) — an implanted brain device — affects eye-hand coordination and visual movement control in people with Parkinson's disease, to help improve DBS programming. **You may be eligible if...** - You have Parkinson's disease and already have bilateral deep brain stimulation (DBS) implants in the subthalamic nucleus (STN) - You have pre-surgery MRI scans available and are able to get post-surgery brain scans - Your Parkinson's symptoms are at a moderate stage when off medication (Hoehn and Yahr stage 2–4) - Your medications and DBS settings have been stable **You may NOT be eligible if...** - You have dementia - You have untreated significant depression or anxiety - You have had other brain surgeries for Parkinson's besides DBS - Your symptoms suggest a different type of movement disorder (atypical parkinsonism) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Louis Stokes VA Medical Center, Cleveland, OH

Cleveland, Ohio, United States

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NCT05400499


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