RecruitingNCT05406232

Temporal Immunologic Changes With Hypofractionated Radiation-Induced DNA Damage in Breast Cancer

Breast Radiation-induced Immunologic Genomic Hypofractionated Temporal Radiation Alterations DNA Damage (BRIGHT-RAD) Study.

Sponsor

M.D. Anderson Cancer Center

Enrollment

20 participants

Start Date

Sep 15, 2023

Study Type

OBSERVATIONAL

Conditions

Breast Carcinoma Invasive Breast Carcinoma

Summary

This study assesses changes to the immune cells following hypofractionated radiation-induced DNA damage in breast cancer patients. Radiation therapy may cause immune cells to enter tumors and target cancer cells. The goal of this study is to measure the change in the level of immune cells in the tumor before and after radiation therapy.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at how the immune system changes in breast cancer patients who receive a type of focused, short-course radiation therapy (called hypofractionated radiation). Researchers want to understand if and how radiation causes immune responses that might help fight the cancer. **You may be eligible if...** - You are 18 or older - You have been diagnosed with invasive breast cancer confirmed by biopsy - Your tumor is close enough to the skin surface to allow a punch biopsy - Your doctor believes you would benefit from palliative radiation to the breast or chest wall **You may NOT be eligible if...** - You previously had radiation to the same area that cannot safely be repeated - You are pregnant - You are on blood thinners (anticoagulants) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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