MOTIV BTK Randomized Controlled Trial

This study tests a special type of drug-eluting scaffold (a tiny mesh tube that slowly releases medication) in arteries below the knee for people with critical limb ischemia — a severe circulation problem where too little blood reaches the legs, threatening the limb. You may be eligible if: - You are at least 18 years old - You have critical limb ischemia classified as Rutherford category 4 or 5 - You have a significant artery blockage in a vessel below the knee that meets specific size and location requirements You may NOT be eligible if: - Your expected survival is less than 1 year - You had a stroke within 3 months or a heart attack within 30 days - You have kidney failure (eGFR < 30 mL/min) - You require a major amputation - You are pregnant or nursing - You have active infection or a coagulation disorder Talk to your doctor to see if this trial is right for you.