Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).
Ohio State University
200 participants
Mar 1, 2023
OBSERVATIONAL
Conditions
Summary
The aim of this study is to identify and determine the levels of oxidized lipids and lipid mediators following exposure to oxygen supplementation during mechanical ventilation by oxidative lipidomics. The investigators will include patients with mechanical ventilation and have received FiO2=\>0.5 atleast 90 minutes and collected two sequential mini bronchoalveolar lavage on them 24 hours apart. Mass Spectrometry Lipid chromatography will be conducted and clinical data will be analyzed.
Eligibility
Inclusion Criteria1
- Adults age => 18 and needing Mechanical ventilation in Intensive Care unit expected atleast for 48 hours
Exclusion Criteria5
- Mechanical ventilation, only needed for performing procedures- bronchoscopy, esophagogastroduodenoscopy, colonoscopy, or others
- Chronic respiratory failure prior to admission;
- Hemoptysis or diffuse alveolar hemorrhage
- Medication use such as N acetyl cysteine; aspirin, fish oil supplements.
- Primary team prohibits bronchoscopy for a specific clinical indication or safety;
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Interventions
oxygen exposure of more than 50% for 1.5 hours
Locations(1)
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NCT05412810