Inhaled Isopropyl Alcohol for Treatment of Nausea
Inhaled Isopropyl Alcohol for the Treatment of Nausea in a Pediatric Emergency Department: A Open Label, Randomized Controlled Clinical Trial
State University of New York at Buffalo
84 participants
Apr 20, 2022
INTERVENTIONAL
Conditions
Summary
To determine the efficacy of inhaled isopropyl alcohol in treating nausea/vomiting among pediatric patients compared with the conventional ondansetron, or placebo treatment in a tertiary care pediatric emergency department.
Eligibility
Inclusion Criteria4
- Patients with a chief complaint of nausea or vomiting
- Ages 7-178 years, both sexes
- Weight ≥ 15 kg
- Baxter Animated Retching Faces (BARF) nausea severity score ≥ 4/10
Exclusion Criteria11
- \. Require IV access
- Inability to breathe in/out through the nose
- Anosmia (self- or parental report)
- Allergy to isopropyl alcohol or ondansetron
- Current or history of alcohol abuse
- Inability to communicate feeling nauseous
- Inability to follow directions regarding taking deep breaths through the nose
- Known prolonged QT interval
- Pregnancy
- Received antiemetics within the last 8 hours
- Currently taking apomorphine
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Interventions
Isopropyl alcohol pad (Covidien Webcol 2 ply prep pads, saturated with 70% isopropyl alcohol) held 1-2 cm under the subject's nares
4 mg oral disintegrating ondansetron tablet once
Normal saline pad (Hygea sterile saline wipe) held 1-2 cm under the subject's nares
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05418244