Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome
Vanderbilt University Medical Center
60 participants
Jun 1, 2022
INTERVENTIONAL
Conditions
Summary
The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections. This syndrome affects mostly women (\~80%), present with chronic tachycardia and Orthostatic intolerance symptoms without any identifiable cause. In addition, non-specific symptoms such as fatigue, headache, and "brain fog", commonly described in POTS patients are also present in this novel condition, recently named post-COVID-19 tachycardia syndrome, POTS variant. Reduced Vagal activity and unresolved inflammation is post-COVID-19 POTS is hypothesized as the cause of Long COVID
Eligibility
Inclusion Criteria2
- Prior RT-PCR-confirmed COVID-19 infection.
- Post-COVID-19 POTS will be defined as the presence of orthostatic tachycardia (>30 bpm) and chronic (>3 months) pre-syncopal symptoms.
Exclusion Criteria14
- Heart Disease: Myocardial Infarction, angina, heart failure
- History of stroke, or transient ischemic attack
- Undergone an invasive procedure for CVD (coronary artery bypass graft, angioplasty, valve replacement, pacemaker placement or other vascular surgeries)
- Uncontrolled hypertension defined as persistent blood pressure >140/90.
- Post-menopausal women.
- Diabetes Mellitus Type 1 or Type 2. ,
- Impaired Hepatic function
- Impaired renal function test (eGFR<60 mL/min/1.73m2).
- Ongoing substance abuse.
- Mental conditions rendering a subject unable to understand the nature, scope and possible consequences of the study.
- History of seizures.
- Chronic use of steroids, NSAIDs.
- On biologics such as anti-IL6 (omalizumab) and anti-TNF-alpha drugs
- Pregnancy or breastfeeding
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Interventions
Inflammatory and immune profile of post-COVID-19 POTS patients. Reduced PNS activity (vagal tone) in relation to persistent inflammation.
Inflammatory and immune profile of healthy controls. Controls are the subjects who recovered from COVID-19 infection with no sequelae.
Inflammatory biomarkers after restoring PNS function in post-COVID-19 POTS patients, by chronic transcutaneous vagus nerve stimulation (tVNS) in post COVID-19 POTS patients
Locations(1)
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NCT05421208