Long COVID Clinical Trials

81 recruitingLast updated: June 18, 2026

There are 81 actively recruiting long covid clinical trials across 22 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1, Phase 4. Top locations include Boston, Massachusetts, United States, New York, New York, United States, Toronto, Ontario, Canada. Updated daily from ClinicalTrials.gov.


Long COVID Trials at a Glance

81 actively recruiting trials for long covid are listed on ClinicalTrialsFinder across 6 cities in 22 countries. The largest study group is Not Applicable with 33 trials, with the heaviest enrollment activity in Boston, New York, and Toronto. Lead sponsors running long covid studies include Icahn School of Medicine at Mount Sinai, VA Office of Research and Development, and Vanderbilt University Medical Center.

Browse long covid trials by phase

Treatments under study

About Long COVID Clinical Trials

Looking for clinical trials for Long COVID? There are currently 72 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Long COVID trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Long COVID clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 81 trials

Recruiting
Phase 1

PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)

Post Acute Sequelae of COVID-19Long COVID
National Institute of Mental Health (NIMH)60 enrolled1 locationNCT06920628
Recruiting
Not Applicable

Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog

Long COVID
Mayo Clinic45 enrolled1 locationNCT06614309
Recruiting

Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID?

Long COVID Syndrome
York University30 enrolled1 locationNCT07312409
Recruiting

Long-Term Health Effects of Previous Coronavirus Disease 2019 (COVID-19) in Patients Undergoing Preoperative Anesthesia Evaluation

Long COVIDPost-COVID ConditionSequelae of COVID-19
Elazıg Fethi Sekin Sehir Hastanesi400 enrolled1 locationNCT07435805
Recruiting
Phase 2

Evaluating the Safety and Efficacy of PNMR as Treatment for Long COVID

Long COVID
ParagonClinicals Inc.82 enrolled4 locationsNCT07627815
Recruiting
Phase 2Phase 3

Taurine Supplementation in Long COVID

Long COVID
University of Alberta300 enrolled5 locationsNCT06721949
Recruiting
Phase 1

Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease

Long COVIDSARS CoV-2Neurodegeneration+1 more
Stephanie B. Seminara, MD40 enrolled1 locationNCT07224490
Recruiting
Phase 3

Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19

Long Covid 19
Icahn School of Medicine at Mount Sinai80 enrolled1 locationNCT06960928
Recruiting
Phase 2

A Study to Examine Anktiva for the Treatment of COVID-19.

Long COVIDLong COVID SyndromeLong Covid 19
ImmunityBio, Inc.40 enrolled1 locationNCT07123727
Recruiting
Phase 2

A Study to Assess Anktiva in Patients With Long Covid-19.

Long COVID
ImmunityBio, Inc.20 enrolled1 locationNCT07108036
Recruiting
Phase 3

Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID

SARS-CoV-2 infectionCOVID-19Long COVID+1 more
Wes Ely550 enrolled17 locationsNCT06631287
Recruiting

Mitochondrial Function in Peripheral Blood Mononuclear Cells, Muscle, and Skin of Long COVID Patients

Post COVID-19 ConditionLong COVID
Universitair Ziekenhuis Brussel54 enrolled1 locationNCT07134673
Recruiting

Institut de Recherche Cliniques de Montreal (IRCM) Post-COVID-19 (IPCO) Research Clinic

COVID19Long COVID
Emilia Falcone, MD650 enrolled1 locationNCT04736732
Recruiting
Not Applicable

Evaluating the Impact of a Functional and Cognitive Strategy in Patients With Long Covid-19

Long COVID-19 SyndromeDiabetes MellitusHypertension+3 more
Fundación Cardioinfantil Instituto de Cardiología374 enrolled1 locationNCT06871293
Recruiting
Not Applicable

Long COVID Brain Fog: Cognitive Rehabilitation Trial

Cognitive ImpairmentCognitive DysfunctionPost-Acute COVID-19 Syndrome+2 more
University of Alabama at Birmingham30 enrolled1 locationNCT06095297
Recruiting
Phase 2

Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC)

Post COVID-19 ConditionLong COVIDLong COVID Syndrome+2 more
Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia90 enrolled1 locationNCT06766825
Recruiting
Phase 2Phase 3

Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)

Long COVIDSmell DysfunctionOlfactory Disorder
Medical University of South Carolina145 enrolled1 locationNCT05855369
Recruiting
Phase 3

Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study

Long COVID
Douglas D. Fraser348 enrolled9 locationsNCT06928272
Recruiting

Immune-mediated Pathogenic Mechanisms of Neuro-PASC in Veterans

Long COVIDNeuro-PASC
VA Office of Research and Development200 enrolled2 locationsNCT06932237
Recruiting
Phase 2

DAOIB for the Treatment of Brain Fog

Long COVID
Chang Gung Memorial Hospital40 enrolled1 locationNCT05764538