PG2 Injection for the Treatment of moderate-to Severe Fatigue in Breast Cancer Patients

This study is testing PG2, an herbal injection made from Astragalus, to see if it can reduce moderate to severe tiredness (fatigue) in women with breast cancer who are receiving chemotherapy through an IV. **You may be eligible if...** - You are a woman aged 20 or older - You have locally advanced, recurrent, or metastatic breast cancer and are currently on IV chemotherapy - You have been experiencing moderate to severe cancer-related fatigue (rated 4 or above on a 0-10 scale on at least two occasions, at least 14 days apart) - Your blood counts and organ function are within acceptable ranges - Your pain is adequately controlled (4 or below on a 0-10 scale) - Your life expectancy is at least 3 months **You may NOT be eligible if...** - You have brain metastases or a primary brain tumor - You have a psychiatric condition or substance abuse disorder - You are currently pregnant or breastfeeding - You are using opioid pain medications - You have a known allergy to Astragalus products - You are taking medications for alcohol use disorder or herbal/dietary supplements marketed for energy Talk to your doctor to see if this trial is right for you.