RecruitingPhase 2NCT07001241

Telehealth Exercise Program Evaluating Fatigue and Physical Function in Rural Cancer Survivors

Effects of a Telehealth Exercise Program for Rural Cancer Survivors With Cancer-related Fatigue Including Integrated Longitudinal Assessments of Objective Physical Function and Fatty Acid Oxidation

Sponsor

University of Colorado, Denver

Enrollment

134 participants

Start Date

Oct 8, 2025

Study Type

INTERVENTIONAL

Conditions

Breast Cancer Prostate Cancer Cancer-related Fatigue

Summary

This study investigates the efficacy of a telehealth exercise program designed specifically for rural cancer survivors with cancer-related fatigue (CRF). Small dried blood samples and measures of physical function will be collected throughout the program. The main questions it aims to answer are: * Does the exercise program improve CRF in rural cancer survivors? * How do CRF, metabolism, and physical function change during the exercise program? Researchers will compare the program to a wait-list control group. This group will complete all study measures without without changing current physical activity before receiving the full exercise program. Participants will: * Complete a virtual physical assessment before and after the program. * Complete brief virtual assessments and collect dried blood samples (at home and mailed in) every two weeks during the program. * Receive a personalized exercise program including virtual sessions and remote exercise programming with a cancer exercise specialist (after a 12-week wait period in the wait-list control group). * Optional: Willing participants will visit a study site for a laboratory-based exercise assessment before and after the program.

Eligibility

Min Age: 18 YearsMax Age: 89 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a telehealth (online video) exercise program to see whether it can reduce fatigue and improve physical fitness in cancer survivors living in rural areas who are too far from in-person programs. **You may be eligible if...** - You are 18–89 years old with a history of breast or prostate cancer - You completed cancer treatment (not just surgery alone) between 3 months and 5 years ago - You live in a rural area as defined by federal guidelines - You experience at least moderate fatigue (rated 3 or higher out of 10) - You have high-speed internet and a smartphone or laptop with a front-facing camera **You may NOT be eligible if...** - You only had surgery and no other cancer treatment - You are not a rural resident - You are experiencing very little fatigue - Your doctor has not cleared you for exercise - You have conditions that would make exercise unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALTelehealth Exercise Program

BfitBwell-TP is a 12-week telehealth exercise intervention. Exercise prescriptions are created, personalized, and delivered by Cancer Exercise Specialists. Exercise content is delivered using a combination of videoconference sessions and a commercial personal training application (accessible via smartphone or internet browser). Patient-reported symptoms (specifically cancer-related fatigue) are assessed every two weeks via emailed surveys. Survey scores are compared to a reference chart of predicted improvements during the program, developed from an established clinical exercise oncology program. Additional videoconference sessions are initiated for participants demonstrating lower than expected symptom improvement, with the goal of adapting the current exercise prescription to improve symptom response.