RecruitingNCT05441839

UK Heart Failure With Preserved Ejection Fraction

UK Heart Failure With Preserved Ejection Fraction Registry

Sponsor

Manchester University NHS Foundation Trust

Enrollment

10,000 participants

Start Date

Oct 7, 2022

Study Type

OBSERVATIONAL

Conditions

Heart Failure With Preserved Ejection Fraction (HFpEF)

Summary

Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness. In about half of patients with heart failure, one measure of the heart's pumping function, called the 'ejection fraction', is normal. This type of heart failure is called heart failure with preserved ejection fraction, or HFpEF. HFpEF remains poorly understood. It is not clear why some people develop HFpEF, or what determines the severity of the condition. Treatment options may be limited. UK HFpEF is a study that aims to gain a better understanding of why people develop HFpEF, develop better tests to diagnosis it, identify and test new treatments, and follow the health of the people taking part over many years.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is building a database (registry) of patients in the UK who have heart failure with preserved ejection fraction (HFpEF) — a type of heart failure where the heart pumps normally but is too stiff. The goal is to better understand what causes it and how to treat it. **You may be eligible if...** - You have been diagnosed with HFpEF by a qualified cardiologist, primary care physician, or heart failure nurse - Your natriuretic peptide levels (a blood marker for heart failure) have been measured - You can provide written informed consent **You may NOT be eligible if...** - Your heart's pumping function is significantly reduced (ejection fraction below 40%) - You have been diagnosed with certain specific types of heart disease such as amyloidosis, hypertrophic cardiomyopathy, myocarditis, or severe valve disease - You have had a heart transplant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(26)

Cwm Taf Morgannwg University Health Board

Abercynon, United Kingdom

Buckinghamshire Healthcare NHS Trust

Aylesbury, United Kingdom

University Hospitals Birmingham NHS Foundation Trust

Birmingham, United Kingdom

Broomfield Hospital

Chelmsford, United Kingdom

NHS Tayside

Dundee, United Kingdom

Glasgow Royal Infirmary

Glasgow, United Kingdom

West Suffolk NHS Foundation Trust

Ipswich, United Kingdom

Kettering General Hospital

Kettering, United Kingdom

Leeds Teaching Hospitals NHS Trust

Leeds, United Kingdom

University Hospitals of Leicester NHS Foundation Trust

Leicester, United Kingdom

Barnet Hospital

London, United Kingdom

Guys and St. Thomas' NHS Foundation Trust

London, United Kingdom

Imperial College Healthcare NHS Trust

London, United Kingdom

Manchester University NHS Foundation trust

Manchester, United Kingdom

The James Cook University Hospital

Middlesbrough, United Kingdom

Northumbria Healthcare NHS Foundation Trust

Newcastle upon Tyne, United Kingdom

Norfolk & Norwich University Hospitals NHS Foundation Trust

Norwich, United Kingdom

George Eliot Hospital

Nuneaton, United Kingdom

North West Anglia NHS Foundation Trust

Peterborough, United Kingdom

University Hospitals Dorset NHS Foundation Trust

Poole, United Kingdom

Betsi Cadwaldr University Health Board

Rhyl, United Kingdom

Salisbury NHS Foundation Trust

Salisbury, United Kingdom

Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield, United Kingdom

University Hospital of North Tees

Stockton-on-Tees, United Kingdom

South Tyneside & Sunderland NHS Foundation Trust

Sunderland, United Kingdom

Southend University Hospital

Westcliff-on-Sea, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT05441839

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