Rh-PDGF vs EMD for Treatment of Intra-bony Defects

This study compares two treatments applied to pockets between the teeth and gum that are caused by periodontitis (gum disease with bone loss): one uses a growth factor protein called rh-PDGF, and the other uses enamel matrix proteins (EMD, also known as Emdogain). Both are injected into the bone defect during gum surgery to help regenerate lost bone and gum tissue. You may be eligible if: - You are 18 or older with no serious medical conditions - You recently completed scaling and root planing for gum disease - You have a deep pocket (6 mm or more) with at least 3 to 6 mm of bone loss - Your overall oral hygiene (plaque and bleeding scores) is below 20% - You are available for 6-month follow-up You may NOT be eligible if: - You are pregnant or planning to become pregnant during the study - You smoke more than 10 cigarettes a day - You have uncontrolled diabetes (HbA1c above 7.5) - You take medications that affect the gums (such as phenytoin or alendronate) - There is an abscess or infection at the root of the treated tooth Talk to your doctor to see if this trial is right for you.