RecruitingPhase 1Phase 2NCT05444088

Study of SHR-8068 Combined With Adebrelimab and Bevacizumab in the Treatment of Advanced Hepatocellular Carcinoma

An Open-label, Multicenter Phase Ib/II Clinical Study of SHR-8068 Combined With Adebrelimab and Bevacizumab in the Treatment of Advanced Hepatocellular Carcinoma


Sponsor

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Enrollment

129 participants

Start Date

Aug 2, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

To evaluate the tolerability and safety of SHR-8068 in combination with Adebrelimab and Bevacizumab in subjects with advanced HCC; To evaluate the efficacy of SHR-8068 in combination with Adebrelimab and Bevacizumab in subjects with advanced HCC.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of three drugs — SHR-8068, adebrelimab (an immunotherapy), and bevacizumab (a drug that blocks blood vessel growth) — in people with advanced liver cancer (hepatocellular carcinoma or HCC) that cannot be surgically removed. **You may be eligible if...** - You are between 18 and 75 years old - You have advanced liver cancer confirmed by pathology - You have not received prior immunotherapy for liver cancer - You have had no more than 1 prior line of treatment - Your overall health and liver function are adequate - You have at least one measurable tumor **You may NOT be eligible if...** - You have a rare subtype of liver cancer (fibrolamellar, sarcomatoid, or mixed cholangiocarcinoma) - Your liver function is severely impaired - You have active autoimmune disease or severe infections - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAdebrelimab

intravenous infusion

DRUGBevacizumab

intravenous infusion

DRUGSHR-8068

intravenous infusion


Locations(1)

Anhui Provincial Hospital Ethics Commitee

Hefei, Anhui, China

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NCT05444088


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