RecruitingPhase 2NCT05446376

Contribution of PET/CT With Gallium 68 Citrate (68Ga-PET/CT) for the Diagnosis of Prosthetic Valve Infective Endocarditis

Sponsor

University Hospital, Bordeaux

Enrollment

40 participants

Start Date

Nov 22, 2024

Study Type

INTERVENTIONAL

Conditions

Infective Endocarditis

Summary

CiGal-EI-TEP is an exploratory study that aim to assess the diagnostic performance of 68Ga Positron emission tomography (PET) / Computed Tomography (CT) for the diagnosis of prosthetic valve infective endocarditis in comparison with the final diagnosis established according to the ESC 2023 criteria, after 3 months of follow-up, by a panel of experts.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

adult patient (over 18 years old);
patient with a prosthetic heart valve;
patient suspected of infective endocarditis (on clinical and/or microbiological and/or imaging data);
patient whose history is discussed in the multidisciplinary meeting dedicated to endocarditis;
patient beneficiary of a social security scheme;
free, informed and written consent signed by the participant and the investigator.

Exclusion Criteria5

pregnant or breastfeeding women;
women of childbearing potential not using effective contraception;
patients referred to in articles L.1121-5 to L.1121-8 (persons deprived of liberty by judicial or administrative decision, minors, adults subject to a legal protection measure or unable to express their consent);
subject in a period of relative exclusion due to another protocol;
known contraindication to PET/CT with injection of radiotracers (hypersensitivity to radiopharmaceuticals and/or excipients).

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