RecruitingPhase 1NCT05451251

Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pontine Lesion

Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pontine Lesion: a Pilot Study


Sponsor

Université de Sherbrooke

Enrollment

6 participants

Start Date

Oct 15, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of this study is to assess the feasibility of deep brain stimulation for refractory trigeminal neuralgia due to a pontine lesion, as is usually seen in the context of multiple sclerosis. These patients usually have severe intractable facial pain and current medical and surgical options generally fail to achieve long lasting pain relief. Hoping to improve pain control in this population, the investigators of this trial propose a novel technique consisting of implanting a deep brain stimulation lead within the pontine lesion to modulate the generation of pain signals.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests deep brain stimulation (DBS) — a surgery that implants a device that sends electrical signals to specific brain areas — for people with severe, treatment-resistant trigeminal neuralgia caused by a lesion in the brainstem. Trigeminal neuralgia causes extreme facial pain that is often described as one of the most painful conditions known. **You may be eligible if...** - You have been diagnosed with trigeminal neuralgia (severe, shock-like facial pain) - Your pain is caused by a lesion in the pons (part of the brainstem) - You have tried medications and other treatments without adequate relief - You are an adult in generally good health for surgery **You may NOT be eligible if...** - Your pain has not been clearly linked to a brainstem lesion - You have conditions that make brain surgery unsafe - You have a cardiac pacemaker or other implanted device that could interfere with DBS - You have active psychiatric conditions that could complicate surgery or recovery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEDeep brain stimulation

Implantation of deep brain stimulation lead within the pontine lesion


Locations(1)

Centre Hospitalier Universitaire de Sherbrooke (CHUS)

Sherbrooke, Quebec, Canada

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NCT05451251


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