Multiomics Biomarkers for Urolithiasis

This study is looking for biological markers (from blood, urine, or tissue) that can help explain why some people get kidney stones repeatedly. Understanding these biomarkers may lead to better prevention and treatment of recurrent kidney stones. You may be eligible if: - You are 18 or older - You have a history of 2 or more kidney stone episodes (both sides count as separate episodes) - OR you have never had a kidney stone and are willing to serve as a healthy comparison participant You may NOT be eligible if: - You refuse or are unable to give consent - You have an active urinary tract infection - Your stones are radiolucent (not visible on standard X-ray) or are infection-related stones Talk to your doctor to see if this trial is right for you.