Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation

This study focuses on improving how doctors monitor and protect the lungs and breathing muscle (diaphragm) in patients who need a breathing machine (mechanical ventilator). When patients are on a ventilator, too much or too little pressure can injure the lungs and weaken the diaphragm. This study tests new tools to visualize breathing effort and lung mechanics in real time, helping doctors fine-tune ventilator settings. You may be eligible if: - You are older than 28 days of age - You weigh more than 3 kilograms (about 6.6 lbs) - You require invasive mechanical ventilation (a breathing tube connected to a machine) - You are expected to need ventilation for more than 48 hours You may NOT be eligible if: - Consent is refused - You have been on a ventilator within the past 2 weeks before joining the study - You have a known abnormality in the shape of your diaphragm (including congenital diaphragmatic hernia) - There is a medical reason you cannot have a special measurement tube placed through the nose into the esophagus Talk to your doctor to see if this trial is right for you.