Association Between Body Composition and Pain in Spinal Cord Injury
Association Among Body Composition, Chronic Pain, Evoked Pain Sensitivity, and Adiposity-related Systemic Inflammation in Individuals With Spinal Cord Injury
University of Miami
40 participants
Feb 20, 2023
INTERVENTIONAL
Conditions
Summary
The purposes of the study are to quantify and compare relationships among acute changes in inflammatory markers and evoked pain sensitivity after a high-fat meal (HFM) challenge, compared to a moderate-fat meal challenge, and explore the influence of body composition on these responses, in individuals with chronic spinal cord injury
Eligibility
Inclusion Criteria5
- Age 18-70 years
- Spinal cord injury occurring at least 2 years prior to study entry
- Neurological level of injury (LOI) between C4 and L2
- American Spinal Injury Association Impairment Scale (AIS) A-D
- English-speaking.
Exclusion Criteria6
- Cognitive dysfunction that limits ability to adequately understand the risks of the study or are otherwise unable to consent
- Health conditions associated with chronic systemic inflammation unrelated to weight or adiposity (e.g., systemic autoimmune diseases, recurrent or active urinary tract infection, pressure injury \> Stage 2)
- Conditions that preclude measurement of body composition by dual-energy x-ray absorptiometry (DXA; e.g., lower limb contracture \> 15 degrees)
- Inability to obtain free-flowing blood from a superficial forearm or hand vein
- Pregnant women
- Prisoners
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Interventions
A liquid meal consisting of powdered protein and complex carbohydrates blended with coconut oil and peanut butter in ratios required to achieve the desired calorie and macronutrient distributions of a normal/moderate fat meal.
A liquid meal consisting of powdered protein and complex carbohydrates blended with coconut oil and peanut butter in ratios required to achieve the desired calorie and macronutrient distributions of a high-fat meal.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05459207