RecruitingPhase 3NCT05460416
Treatment Preventive for Pre-eclampsia by Acetylsalicylic Acid in Women Who Underwent Frozen Embryo Transfer
A Prospective Interventional Randomized Controlled Trial to Assess the Effect of Low Dose Acetylsalicylic Acid As a Preventive Treatment of Pre-eclampsia in Pregnant Women Who Underwent Frozen Embryo Transfer
Sponsor
Centre Hospitalier Universitaire de Liege
Enrollment
276 participants
Start Date
Oct 25, 2022
Study Type
INTERVENTIONAL
Conditions
Summary
Title: A prospective multicentric interventional randomized controlled trial to assess the effect of low dose acetylsalicylic acid as a preventive treatment of pre-eclampsia in pregnant women who underwent frozen embryo transfer
Eligibility
Sex: FEMALEMin Age: 18 YearsMax Age: 43 Years
Inclusion Criteria3
- Healthy women from \[18 - 43\] years-old, planned for a frozen embryo transfer, with natural and modified natural or HRT cycle
- Who have given their informed consent
- Who have a confirmed pregnancy at week 6 of amenorrhea.
Exclusion Criteria4
- Women presenting one risk factor for preeclampsia: multiple pregnancy, history of preeclampsia, BMI \> 30, lupus syndrome, preexistent proteinuria, non-treated chronic high blood pressure (\>140/90), antiphospholipid antibody syndrome, diabetes (fasting blood sugar \>126mg/dl)
- Contraindication to acetylsalicylic acid (at risk of active hemorrhage (like hemophilia, …); at risk of or who have a gastro-duodenal ulcer; at risk or how have a terminal renal or hepatic in-sufficiency (only if acetylsalicylic acid is given at high dose)
- Already treated with acetylsalicylic acid
- Treatment with anticoagulants or non-steroid anti-inflammatory drugs
Interventions
DRUGAcetylsalicylic acid
160mg once a day
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05460416
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