RecruitingPhase 1Phase 2NCT05465538
SV2A in Older Adults
Effect of Cannabis Use on Synaptic Density in Older Adults
Sponsor
Yale University
Enrollment
24 participants
Start Date
Jul 6, 2022
Study Type
INTERVENTIONAL
Conditions
Summary
The aim of the study is to examine the effect of cannabis use on brain synaptic density among older adults using \[11C\]UCB-J PET imaging.
Eligibility
Min Age: 50 Years
Inclusion Criteria5
- Able to provide informed consent
- Male or female, aged ≥50 years
- No history of significant medical or neurological disease
- BMI ≤ 50
- If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans
Exclusion Criteria4
- Women with a positive pregnancy test or women who are lactating
- Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits;
- History of a bleeding disorder or are currently taking anticoagulants
- Subjects who have donated blood within 8 weeks of the present study
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Interventions
DRUG[11C]UCB-J PET
Single PET scan using the radioligand \[11C\]UCB-J
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05465538
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