RecruitingPhase 1Phase 2NCT05465538

SV2A in Older Adults

Effect of Cannabis Use on Synaptic Density in Older Adults

Sponsor

Yale University

Enrollment

24 participants

Start Date

Jul 6, 2022

Study Type

INTERVENTIONAL

Conditions

The aim of the study is to examine the effect of cannabis use on brain synaptic density among older adults using \[11C\]UCB-J PET imaging.

Min Age: 50 Years

Able to provide informed consent
Male or female, aged ≥50 years
No history of significant medical or neurological disease
BMI ≤ 50
If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans

Women with a positive pregnancy test or women who are lactating
Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits;
History of a bleeding disorder or are currently taking anticoagulants
Subjects who have donated blood within 8 weeks of the present study

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