Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease Participants
A Randomized, Participant and Investigator Blinded, Placebo-Controlled Study to Evaluate the Ability of a Single Intrathecally Administered Dose of NIO752 to Lower Cerebrospinal Fluid Total Tau Levels in Participants With Early Alzheimer's Disease
Novartis Pharmaceuticals
36 participants
Feb 23, 2023
INTERVENTIONAL
Conditions
Summary
Phase 1b study to assess the pharmacodynamics, safety, tolerability, and pharmacokinetics of NIO752 in patients with early Alzheimer's disease (AD)
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
A single intrathecal (cerebrospinal) injection of NIO752 of Dose A
A single intrathecal (cerebrospinal) injection of NIO752 at dose B
A single intrathecal injection of matching placebo
Multiple intrathecal injections of NIO752 of Dose A
Two intrathecal injections of NIO752 at dose C
Single intrathecal injection of NIO752 at dose C
Two intrathecal injections of matching placebo
Locations(10)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05469360