Taiwan Associated Genetic and Nongenetic Small Vessel Disease
Deciphering, Construction and Validation of Magnetic Resonance Imaging Maps, Clinical Features and Outcomes in Genetic and Nongenetic Cerebral Small Vessel Diseases
National Taiwan University Hospital
500 participants
Jan 1, 2019
OBSERVATIONAL
Conditions
Summary
The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.
Eligibility
Inclusion Criteria8
- Participants must have at least one of the following symptoms/signs or history
- stroke (especially small vessel occlusion type of ischaemic stroke, spontaneous ICH or young stroke)
- cognitive impairment or dementia
- gait disturbance
- parkinsonism (especially vascular parkinsonism features)
- headache (especially migraine)
- positive family history of hereditary CSVD
- MRI evidence of CSVD (MRI may be done for other reasons), including mild to moderate white matter hyper intensity, any lacune, or any cerebral microbleed
Exclusion Criteria2
- MRI evidence of CSVD due to other inflammatory, malignancy, or structural lesions
- patients or family members not willing to sign informed consent
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Interventions
Patients will repeat study-protocol MRI at baseline (enrollment) and at least once in 1 year or 2 years follow-up (depends on availability).
Locations(1)
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NCT05473637