Arginine Metabolism in Youth With Type 2 Diabetes
Arginine Metabolism in Pediatric Type 2 Diabetes
Baylor College of Medicine
30 participants
Feb 6, 2023
INTERVENTIONAL
Conditions
Summary
Type 2 diabetes (T2D), once considered only "a disease of older ages," is now a significant public health concern in youth. Although it is characterized by insulin resistance and impaired insulin secretion, its precise etiology and pathogenesis are not yet fully understood. This study aims to (1) explore arginine metabolism in youth with T2D via safe, minimally invasive kinetic experiments using stable isotope tracers and targeted metabolomics, and (2) determine the effect of exogenous arginine administration on β-cell function in youth with T2D, potentially supporting the use of this safe, low-cost, and readily available nutrient to improve pediatric diabetes outcomes.
Eligibility
Plain Language Summary
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Interventions
On separate study days, each participant will have a stable isotope infusion, ingest oral glucose, and be given an intravenous arginine bolus.
Locations(1)
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NCT05477134