RecruitingNot ApplicableNCT05477134

Arginine Metabolism in Youth With Type 2 Diabetes

Arginine Metabolism in Pediatric Type 2 Diabetes


Sponsor

Baylor College of Medicine

Enrollment

30 participants

Start Date

Feb 6, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Type 2 diabetes (T2D), once considered only "a disease of older ages," is now a significant public health concern in youth. Although it is characterized by insulin resistance and impaired insulin secretion, its precise etiology and pathogenesis are not yet fully understood. This study aims to (1) explore arginine metabolism in youth with T2D via safe, minimally invasive kinetic experiments using stable isotope tracers and targeted metabolomics, and (2) determine the effect of exogenous arginine administration on β-cell function in youth with T2D, potentially supporting the use of this safe, low-cost, and readily available nutrient to improve pediatric diabetes outcomes.


Eligibility

Min Age: 12 YearsMax Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how a body chemical called arginine is processed differently in teenagers and young adults with type 2 diabetes compared to healthy young people. Understanding these differences may help researchers develop better treatments for young people with diabetes. **You may be eligible if...** - You are a girl aged 12–20 (and have started your period) or a boy aged 14–20 (and are fully sexually mature) - You have been diagnosed with type 2 diabetes for at least 3 months but no longer than 10 years - Healthy young people without diabetes may also participate as a comparison group **You may NOT be eligible if...** - You have ever had a diabetic ketoacidosis (a serious diabetes complication) - Your diabetes is poorly controlled (HbA1c above 7.5%) - You have liver, thyroid, hormonal, or kidney problems - You take any diabetes medications other than metformin, insulin, or liraglutide - You are pregnant or on hormone therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERStable isotope infusion, oral glucose ingestion, intravenous arginine bolus

On separate study days, each participant will have a stable isotope infusion, ingest oral glucose, and be given an intravenous arginine bolus.


Locations(1)

Texas Children's Hospital / Baylor College of Medicine

Houston, Texas, United States

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NCT05477134


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