RecruitingNCT05480904

Characterizing Sleep Among Long-term Survivors of Childhood Cancer

Sponsor

St. Jude Children's Research Hospital

Enrollment

120 participants

Start Date

Apr 17, 2023

Study Type

OBSERVATIONAL

Conditions

Solid Tumor ALL, Adult CNS Tumor

Summary

The patients are being asked to take part in this clinical trial because they received cancer treatment as a child at St. Jude. The study comprehensively examines sleep among three distinct diagnostic groups of survivors in the SJLIFE cohort: ALL, CNS tumors, and non-CNS solid tumors. Primary Objective The primary aim of this protocol is to estimate the prevalence of various sleep disorders among long-term survivors of childhood ALL, CNS tumors, and non- CNS solid tumors. Exploratory Objective The exploratory objective of the study is to explore associations between the prevalence of sleep disorders and clinical outcomes collected in SJLIFE.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at sleep problems in long-term survivors of childhood cancer. Researchers want to understand how cancer treatments like radiation to the brain or chest may have affected sleep quality years later, which can impact quality of life. **You may be eligible if...** - You are 18 or older - You survived childhood cancer (diagnosed before age 21) and it has been more than 5 years since your diagnosis - You were treated for ALL (leukemia), certain brain tumors, or solid tumors that received abdominal or chest radiation - You are enrolled in the SJLIFE long-term follow-up study at St. Jude Children's Research Hospital - You speak and understand English and have Wi-Fi access (for remote participants) **You may NOT be eligible if...** - You have an estimated IQ below 80 - You are currently being treated for a sleep disorder - You survived craniopharyngioma or Hodgkin Lymphoma - Your cancer relapsed or you received a stem cell transplant - You have a brain or lung injury unrelated to your cancer treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERNeurocognitive (Thinking) Testing

Intelligence: WASI-II 20 min; Sustained Attention: Conners Continuous Performance Test 3rd ED. 15 min; Memory: California Verbal Learning Test 2nd Ed. 20 min; Visual Selective Reminding 7 min; Processing Speed:Coding/Digit Symbol 3 min; Grooved Pegboard 5 min; Executive Function: Trail Making Test 5 min; Verbal Fluency Test 3 min; Digit Span 5 min; Visuospatial: Rey Complex Figure 10 min; Functional Behavior: CCSS Neurocognitive Questionnaire 5 min.

DIAGNOSTIC_TESTCNS Vital Signs (Thinking) Testing

Attention: Continuous Performance Task 5 mins Processing Speed: Symbol Digit Test 4 mins Executive Function: Shifting Attention 3 min and Stroop Test 5 mins

OTHERHealth Questionnaires, Sleep Surveys & Sleep Diary

The participant will be asked to complete the sleep surveys and sleep diary, FACIT fatigue, and CSALTS Pain Survey These questionnaires will take about 29 minutes to complete. The sleep diary is completed at the time the participant wears the sleep device.

DIAGNOSTIC_TESTEchocardiography/EKG

All echocardiograms will be performed using a General Electric VIVID-7. The LV volume, mass and EF will be calculated using the recommendations of the American Society of Echocardiography

DIAGNOSTIC_TESTPulmonary Function

PFTs will include spirometry, lung volume measurements by body plethysmography and single breath carbon monoxide-diffusion capacity (DLCO).

DEVICERemote Polysomnography

The Sleep Profiler PSG2/WatchPat device will be used to assess nighttime sleep disorders.

DIAGNOSTIC_TESTPhysical Function

This is a test of how your heart and lungs respond to exercise.

Locations(1)

St. Jude Children's Research Hospital

Memphis, Tennessee, United States

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NCT05480904

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