Study to Assess the Ability of the Portable Scalp Cooling System (PSCS) to Prevent Hair Loss

This study is testing a portable scalp cooling device designed to prevent hair loss during chemotherapy. Scalp cooling works by reducing blood flow to hair follicles during treatment, making it harder for the chemotherapy drugs to reach and damage them. **You may be eligible if...** - You are a woman aged 21 or older - You have been diagnosed with Stage I, II, or III breast cancer - You are scheduled to receive a chemotherapy regimen that includes a taxane (paclitaxel or docetaxel) with the goal of curing or reducing your cancer before or after surgery - Your hair has fully recovered from any prior chemotherapy (at least 2 years since the last treatment that caused hair loss) - Your general health status (Karnofsky score) is 80% or higher **You may NOT be eligible if...** - You have significant pre-existing hair loss (female pattern baldness) - You have an autoimmune condition affecting your hair (such as alopecia areata) - You have had whole brain radiation - Your chemotherapy regimen includes an anthracycline (e.g., AC/T, TAC) or does not include paclitaxel or docetaxel - You are taking hormone therapy at the same time as chemotherapy Talk to your doctor to see if this trial is right for you.