RecruitingNot ApplicableNCT05500170

Benefits of Nicotinamide Riboside Upon Cognition and Sleep

The Benefits of Nicotinamide Riboside Upon Cognition and Sleep in Older Veterans


Sponsor

State University of New York at Buffalo

Enrollment

50 participants

Start Date

Apr 4, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), a form of vitamin B3 may increase the expression of brain-derived neurotrophic factor. This study proposes to examine the benefits of NR supplementation on sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor.


Eligibility

Min Age: 65 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a supplement called nicotinamide riboside (NR) — a form of vitamin B3 that the body uses to produce cellular energy — can improve both sleep quality and thinking and memory in people who are reporting poor sleep. NR is available as an over-the-counter supplement, but this study is testing it in a controlled research setting to measure its real effects on the brain and sleep. **You may be eligible if...** - You have poor sleep quality, as measured by a standard questionnaire called the Pittsburgh Sleep Quality Index (a global score above 5 indicates poor sleep) - You are an adult willing to participate in the study **You may NOT be eligible if...** - You show signs of dementia or significant memory impairment, as measured by the VA-SLUMS cognitive test (a score below 20 suggests cognitive decline that may affect participation) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTNicotinamide riboside

Nicotinamide riboside (NR) is a form of vitamin B3, which is found in fruits, vegetables, meat, and milk. NR is converted into nicotinamide adenosine dinucleotide NAD+. Low NAD+ levels have been linked to Alzheimer's disease and sleep disturbances.

DIETARY_SUPPLEMENTPlacebo

The placebo pill will contain micro cellulose powder.


Locations(3)

State University of New York at Buffalo

Buffalo, New York, United States

University at Buffalo State University of New York

Buffalo, New York, United States

Buffalo Veteran Affairs Medical Center

Buffalo, New York, United States

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NCT05500170


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