RecruitingPhase 2NCT05503667

Neoadjuvant Furmonertinib Plus Bevacizumab or Furmonertinib Monotherapy for Resectable and Potentially Resectable Stage III-IVA EGFR Mutation-Positive Lung Adenocarcinoma

Neoadjuvant Furmonertinib Plus Bevacizumab or Furmonertinib Monotherapy for Resectable and Potentially Resectable Stage III-IVA EGFR Mutation-Positive Lung Adenocarcinoma: A Randomized, Controlled, Open-label, Single-center Phase II Clinical Trial


Sponsor

Shanghai Pulmonary Hospital, Shanghai, China

Enrollment

96 participants

Start Date

Feb 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

To explore the efficacy and safety of neoadjuvant furmonertinib combined with bevacizumab in the treatment of resectable and potentially resectable stage III-IVA EGFR mutation-positive lung adenocarcinoma.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of two drugs — furmonertinib (a targeted therapy) and bevacizumab (an anti-blood vessel drug) — given before surgery in patients with lung adenocarcinoma that has a specific EGFR mutation. The goal is to shrink the tumor enough to make surgery possible or more successful. **You may be eligible if...** - You have confirmed lung adenocarcinoma with an EGFR-sensitive mutation (identified by biopsy) - Your cancer is stage III or IVA and has not spread to distant organs - Surgery is potentially possible (either now or after treatment) - Your lung function is adequate and your ECOG score is 0 or 1 **You may NOT be eligible if...** - Your cancer has distant metastases (spread to other organs) - You are pregnant (must have negative test) - Your organ function does not meet the required levels Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFurmonertinib

Furmonertinib 80 mg/day for 16 weeks

DRUGBevacizumab

bevacizumab 400 mg/4 weeks i.v. for 4 times


Locations(1)

Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, China

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NCT05503667


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