RecruitingNot ApplicableNCT07161713

SBU-RESET: RElaxation, Stress Reduction and Epigenetics Trial in Cancer Survivors

Pilot Study of a Social/Behavioral Intervention on Lung, Colon, and Non-Hodgkin's Lymphoma (NHL) Cancer Survivors, Evaluating the Effect of Mind Body Interventions on Patient Reported Outcomes, Inflammation and Epigenetics.

Sponsor

Barbara Nemesure

Enrollment

100 participants

Start Date

Sep 17, 2025

Study Type

INTERVENTIONAL

Conditions

Colon Cancer Lung Cancer (Diagnosis)Lung Adenocarcinoma Lung Adenocarcinoma Stage III Lung Adenocarcinoma Stage IV Lung Adenocarcinoma Metastatic Lung Adenocarcinoma Stage IIIB/IV Lung Adenocarcinoma Stage I Lung Adenocarcinoma Stage II NHL NHL - Non-Hodgkin&Amp;#39;s Lymphoma

Summary

Cancer survivors can experience health issues that cause chronic illness and lower quality of life. Yoga is a well-known holistic approach to health and overall well-being. Mindfulness has many benefits, including improved focus and less stress. This study aims to evaluate if yoga and/or mindfulness has a positive effect on cancer survivors social, emotional and physical well-being as well as their epigenetics. Epigenetics is how the environment can effect your genes; not by changing our DNA, but by turning genes on or off.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

Adults over 18 years old
Primary diagnosis: Lung Cancer, Colon Cancer and Non-Hodgkin's lymphoma (NHL)
Six months post cancer-directed treatment (chemotherapy, targeted and immunotherapy). Patients with active disease (e.g. metastatic colorectal cancer) who are not receiving any cancer-directed treatment are eligible.
Able to provide a saliva sample
Gives informed consent and agrees to be randomly assigned
Able to complete the questionnaire(s) in English.

Exclusion Criteria8

Adults with primary anal and/or primary rectal cancer.
Adult cancer survivors who are currently on an active treatment regimen.
Oral or any pathological conditions that can limit the ability to produce saliva.
Unable to participate in full length study period and follow up thereafter.
Is pregnant or plan to become pregnant during the study period.
Currently practicing yoga or SMART
Those on corticosteroid therapy.
Documented fall or syncope within the last 6 months

Interventions

BEHAVIORALOncology-informed yoga

8 weekly sessions of cancer informed-yoga incorporating light movement, breathing techniques, and some meditation practices

BEHAVIORALSMART

SMART, developed by the Impact Foundation, is an adaptation of Mindfulness-based Stress Reduction (MBSR) approach that incorporates other elements like mindful self-compassion, emotional literacy, and positive psychology principles to address the unique stressors faced by teachers.