RecruitingNCT05504330

Cognitive Decline and Underlying Mechanisms in Asymptomatic Intracranial Artery Stenosis Patients

Cognitive Decline and Underlying Mechanisms in Asymptomatic Intracranial Artery Stenosis Patients: A Cohort Study

Sponsor

Anhui Medical University

Enrollment

100 participants

Start Date

Aug 15, 2022

Study Type

OBSERVATIONAL

Conditions

Cognitive Impairment Cerebrovascular Event Asymptomatic Intracranial Stenosis

Summary

The purpose of this study is to explore the mechanism of cognitive impairment in patients with asymptomatic intracranial atherosclerotic stenosis(ICAS),and to examine the natural history and the pathogenesis of asymptomatic ICAS.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria2

Patients with intracranial stenosis which was defined as stenosis of 50% or more in Intracranial segment of internal carotid artery(C6-C7) and middle cerebral artery (M1).
The degree of stenosis was measured by transcranial doppler, computed magnetic resonance angiography (MRA),tomography angiography (CTA) and digital subtraction angiography (DSA).

Exclusion Criteria4

History of stroke,transient ischemic attack,seizures or unexplained loss of consciousness.
Organic brain defects on MRI T1 or T2 images.
Any history or clinical signs of other severe psychiatric illnesses (like major depression,psychosis or obsessive compulsive disorder).
Implanted pacemaker,medication pump,vagal stimulator,deep brain stimulator. History of substance abuse within the last 6 months.

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Interventions

DRUGAspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin

First of all, ICAS patients were given health education to exhort them to reduce the risk factors of exposure to stroke and get rid of their unhealthy lifestyles. Secondly, for patients in need, standardize their dosage and course of treatment, mainly including antiplatelet drugs and statins. In addition, patients with diabetes and hypertension urge rational medication to control blood pressure and blood glucose level.