RecruitingNot ApplicableNCT05526417

Individualized Prehabilitation for Enhancing Recovery and Surgical Outcomes in Patients Undergoing Radiotherapy and Surgery for Soft Tissue Sarcoma

Pre-Operative ERAS® (Enhanced Recovery After Surgery): Randomized Feasibility Trial of Implementing Individualized Prehabilitation for People Undergoing Neo-Adjuvant Radiotherapy and Lower Limb Soft-Tissue Sarcoma Surgery

Sponsor

Mayo Clinic

Enrollment

30 participants

Start Date

Jun 8, 2022

Study Type

INTERVENTIONAL

Conditions

Soft Tissue Sarcoma Stage I Soft Tissue Sarcoma of the Trunk and Extremities Stage II Soft Tissue Sarcoma of the Trunk and Extremities Stage III Soft Tissue Sarcoma of the Trunk and Extremities

Summary

This clinical trial evaluates whether patients with deep soft tissue sarcomas who receive a tailored prehabilitation exercise regimen during standard radiotherapy and prior to standard of care surgery have better recovery and surgical outcomes than those who do not. Patients undergoing surgery to soft tissue sarcomas are at high risk for post-operative disability, which is associated with high rates of depression and poor health-related quality of life. Prehabilitation is the practice of exercising before surgery to ensure that the patient is in the best possible condition. It allows patients to prepare their bodies for recovery after surgery, which may result in better surgical outcomes, recovery, and quality of life after surgery.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether an individualized exercise and physical preparation program (called prehabilitation) started before radiation and surgery improves recovery and outcomes in people with soft tissue sarcoma of the leg. **You may be eligible if...** - You are 18 or older - You have a confirmed deep soft tissue sarcoma located in the lower limb (leg/thigh/hip region) - Your cancer has not spread to lymph nodes or distant organs (localized disease) - You are of any gender **You may NOT be eligible if...** - Your sarcoma is superficial (located above the fascia, a tissue layer just under the skin) - Your cancer has spread to distant organs or lymph nodes (metastatic disease) - You have sarcomas involving both the upper and lower extremities Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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