5-Day Preoperative Radiation for Soft Tissue Sarcoma

This study is evaluating a shorter, 5-day course of radiation therapy given before surgery for soft tissue sarcoma (a cancer of muscles, fat, and connective tissues). Standard radiation usually takes 5 weeks, and researchers are investigating whether this compressed schedule is just as effective and safe. **You may be eligible if...** - You are 18 or older - You have been diagnosed with soft tissue sarcoma of the arm, leg, trunk, or abdomen (retroperitoneum), confirmed by biopsy - Your doctor has recommended surgery and pre-surgery radiation as part of your standard care - You are in good overall physical condition (KPS ≥ 70 or ECOG 0–2) - You have a life expectancy of at least 6 months **You may NOT be eligible if...** - You have had prior radiation to the area being treated - You are currently participating in another cancer treatment trial - You are planned to receive chemotherapy, targeted therapy, or immunotherapy at the same time as radiation - You are pregnant Talk to your doctor to see if this trial is right for you.