RecruitingNot ApplicableNCT05536154

Etoposide+Cytarabine+PEG-rhG-CSF as First Line Mobilization Regimen of Hematopoietic Stem Cells in Patients With Hematological Malignancies

Prospective, Single-arm, Multicenter Exploratory Clinical Study of the Combination of Etoposide, Cytarabine and PEG-rhG-CSF (EAP Regimen) as First Line Mobilization Regimen of Hematopoietic Stem Cells in Patients With Hematological Malignancies


Sponsor

The Affiliated People's Hospital of Ningbo University

Enrollment

68 participants

Start Date

Nov 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single-arm, multicenter, exploratory clinical study to evaluate the safety and efficacy of the combination of etoposide, cytarabine and PEG-rhG-CSF (EAP regimen) as first line mobilization regimen of hematopoietic stem cells in patients with lymphoma and multiple myeloma. All eligible patients will receive EAP regimen treatment, then the number of CD34+ cells and white blood cells will be monitoring. When the collection standard is met, hematopoietic stem cell collection will be started.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new combination regimen — etoposide, cytarabine, and a long-acting growth factor (PEG-rhG-CSF) — to stimulate stem cell production in the blood before a stem cell transplant. This process, called mobilization, is a necessary step before transplant for blood cancer patients, and researchers are evaluating whether this combination is safe and effective. **You may be eligible if:** - You have lymphoma or multiple myeloma and are a candidate for an autologous (using your own) stem cell transplant - Your general health is good enough for the procedure (ECOG score 0–2) - Your life expectancy is at least 3 months - You understand the study and are willing to participate **You may NOT be eligible if:** - You have serious heart, liver, or kidney problems - You have previously undergone stem cell mobilization - You have active infections or uncontrolled medical conditions - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEtoposide

Day 1\~Day 2: 75mg/m\^2

DRUGCytarabine

Day 1\~Day 2: 200mg/m\^2, q12h

DRUGPEG-rhG-CSF

Day 6: 6mg


Locations(14)

Dongyang People's Hospital

Dongyang, Zhejiang, China

Huzhou central hospital

Huzhou, Zhejiang, China

Jinhua Municipal Central Hospital

Jinhua, Zhejiang, China

Tongde Hospital of Zhejiang Province

Hangzhou, Zhejiang, China

Jinhua People's Hospital

Jinhua, Zhejiang, China

Lishui Municipal Central Hospital

Lishui, Zhejiang, China

Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University

Shaoxing, Zhejiang, China

Shaoxing Second Hospital

Shaoxing, Zhejiang, China

Taizhou Hospital of Zhejiang Province

Taizhou, Zhejiang, China

Taizhou Central Hospital

Taizhou, Zhejiang, China

The Affiliated People's Hospital of Ningbo University

Ningbo, Zhejiang, China

Ningbo Medical Center Lihuili Hospital

Ningbo, Zhejiang, China

The 2nd School of Medicine,WMU/The 2nd Affiliated Hospital and Yuying Children's Hospital of WMU

Wenzhou, Zhejiang, China

The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

View Full Details on ClinicalTrials.gov

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NCT05536154


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