Efficacy and Safety of Edoxaban in Patients With Atrial Fibrillation and Mitral Stenosis

This study is testing whether edoxaban — a blood-thinning pill — is effective and safe for preventing strokes and blood clots in patients who have both atrial fibrillation (an irregular heartbeat) and mitral valve stenosis (a narrowing of one of the heart valves). This group of patients is often excluded from standard blood-thinner trials, so the evidence for treatment is limited. **You may be eligible if:** - You are between 18 and 80 years old - You have been diagnosed with atrial fibrillation (confirmed by ECG) - You have moderate or severe mitral valve stenosis (confirmed by echocardiogram) **You may NOT be eligible if:** - You refuse to give consent - Your atrial fibrillation is caused by a reversible condition (such as post-surgery, thyroid disease, or infection) - You have a mechanical heart valve replacement - You have a blood clotting disorder - You have significant liver disease or high bleeding risk (e.g., recent gastrointestinal bleeding, recent brain surgery, or intracranial hemorrhage) Talk to your doctor to see if this trial is right for you.