Use Muscadine Wine Nutraceuticals to Improve Brain Health, Cognition, and Mental Health
Acute and Chronic Impacts of Muscadine Wine Polyphenols on Cognition, Memory, Mood, and Anxiety in Adults Over 50 Years of Age
University of Florida
25 participants
Aug 30, 2023
INTERVENTIONAL
Conditions
Summary
Previous studies have shown that polyphenol-rich foods can positively affect cognitive functions, memory, and mood in humans. We hypothesize that both acute and chronic intake of muscadine wine polyphenols will improve cognitive performance and mood through regulating the HPA axis, alleviating inflammation and oxidative stress, and/or inhibiting monoamine oxidase activities
Eligibility
Inclusion Criteria3
- Healthy
- BMI (18.5-29.9)
- Body weight ≥110 pounds
Exclusion Criteria12
- Pregnancy
- Breast-feeding
- Smokers
- Diabetic
- Heavy drinkers
- Subjective but not clinically diagnosed cognitive impairment (Montreal cognitive assessment score \<26),
- Inability to understand the cognitive function tasks
- Intake of medication that might influence the outcome of the study (e.g. psychostimulant)
- cannabis product user
- Clinically diagnosed mental illnesses
- Cardiovascular and neurological disorders
- Uncontrolled hypertension
Interventions
dealcoholized muscadine wine with alcohol content \<0.5% with addition of 50ppm of sodium metabisulfite for preservation
this placebo beverage is formulated with matching sugar and organic acid content to the muscadine wine polyphenol. Food coloring is added to match the color of the intervention. 50ppm of sodium metabisulfite for preservation
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05541887