RecruitingNot ApplicableNCT05541887

Use Muscadine Wine Nutraceuticals to Improve Brain Health, Cognition, and Mental Health

Acute and Chronic Impacts of Muscadine Wine Polyphenols on Cognition, Memory, Mood, and Anxiety in Adults Over 50 Years of Age


Sponsor

University of Florida

Enrollment

25 participants

Start Date

Aug 30, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Previous studies have shown that polyphenol-rich foods can positively affect cognitive functions, memory, and mood in humans. We hypothesize that both acute and chronic intake of muscadine wine polyphenols will improve cognitive performance and mood through regulating the HPA axis, alleviating inflammation and oxidative stress, and/or inhibiting monoamine oxidase activities


Eligibility

Min Age: 50 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a dietary supplement made from muscadine grapes (a type of native American grape rich in natural antioxidant compounds called polyphenols) can improve brain health, memory, cognitive function, and mental well-being in healthy adults. Participants will take the supplement daily and be tested before and after to measure any changes. **You may be eligible if:** - You are a healthy adult - Your BMI is between 18.5 and 29.9 (normal to slightly overweight) - You weigh at least 110 pounds **You may NOT be eligible if:** - You are pregnant or breastfeeding - You smoke - You have diabetes - You are a heavy drinker - You have a diagnosed mental illness, cardiovascular disease, or neurological disorder - You have uncontrolled high blood pressure - You take medications that could affect the study outcomes (such as stimulants) - You use cannabis products Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMuscadine Wine Polyphenol

dealcoholized muscadine wine with alcohol content \<0.5% with addition of 50ppm of sodium metabisulfite for preservation

OTHERPlacebo

this placebo beverage is formulated with matching sugar and organic acid content to the muscadine wine polyphenol. Food coloring is added to match the color of the intervention. 50ppm of sodium metabisulfite for preservation


Locations(1)

Food Science and human nutrition department at University of Florida

Gainesville, Florida, United States

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NCT05541887


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