Mood Clinical Trials

103 recruitingLast updated: June 18, 2026

There are 103 actively recruiting mood clinical trials across 20 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Early Phase 1. Top locations include Aurora, Colorado, United States, Bethesda, Maryland, United States, Toronto, Ontario, Canada. Updated daily from ClinicalTrials.gov.


Mood Trials at a Glance

103 actively recruiting trials for mood are listed on ClinicalTrialsFinder across 6 cities in 20 countries. The largest study group is Not Applicable with 55 trials, with the heaviest enrollment activity in Aurora, Bethesda, and Toronto. Lead sponsors running mood studies include National Institute of Mental Health (NIMH), University of Colorado, Denver, and Northumbria University.

Browse mood trials by phase

Treatments under study

About Mood Clinical Trials

Looking for clinical trials for Mood? There are currently 50 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Mood trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Mood clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 103 trials

Recruiting

Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder

Mood Disorder
National Institute of Mental Health (NIMH)2,350 enrolled1 locationNCT00025935
Recruiting
Phase 2

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

DepressionDepressive DisorderMolecular Mechanisms of Pharmacological Action+10 more
National Institute of Mental Health (NIMH)50 enrolled1 locationNCT06511908
Recruiting

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

DepressionHealthy VolunteersAnxiety Disorders+2 more
National Institute of Mental Health (NIMH)16,000 enrolled1 locationNCT00024635
Recruiting

Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders

Anxiety DisordersMood Disorders
National Institute of Mental Health (NIMH)390 enrolled1 locationNCT00397111
Recruiting
Not Applicable

Patient-clinical Linkages to Improve Trust and Engagement in Postpartum Healthcare

ContraceptionMaternal BehaviorHealth Literacy+4 more
Jackson State University250 enrolled1 locationNCT06481631
Recruiting
Not Applicable

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

Anxiety DepressionDepressionAnxiety+3 more
University of Pittsburgh150 enrolled3 locationsNCT05658796
Recruiting
Not Applicable

Effects of Binaural Beats and Spatialized Music on Behavioural and Psychological Symptoms of Dementia in Assisted Living Facility Residents

BPSDWell-beingMood+1 more
Maharishi International University120 enrolled2 locationsNCT07626944
Recruiting
Not Applicable

Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders

Psychotic DisordersAnxiety DisordersMood Disorders
Parnassia Groep2,500 enrolled9 locationsNCT05656469
Recruiting
Not Applicable

Impact of a Novel Functional Snack on Perimenopausal Symptoms and Well-being

Quality of LifeSleepGut Microbiota+3 more
King's College London20 enrolled1 locationNCT07599930
Recruiting
Not Applicable

Impact of Bright Light Therapy on Prader-Willi Syndrome

Body WeightPrader-Willi SyndromeBehavior+3 more
Maimonides Medical Center50 enrolled1 locationNCT05939453
Recruiting
Not Applicable

A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences

Psychotic DisordersAnxiety DisordersMood Disorders
Massachusetts General Hospital192 enrolled1 locationNCT06929442
Recruiting
Not Applicable

Feasibility and Acceptability of an E-learning Dialectical Behavior Therapy Skills Course

DepressionStressAnxiety+2 more
University of Windsor40 enrolled1 locationNCT07088939
Recruiting
Not Applicable

Efficacy of Remote Monitoring in Patients Treated for Moderate to Severe Major Depressive Episodes

Mood Disorder (Depressive Episodes)
Resilience594 enrolled6 locationsNCT07087353
Recruiting

Investigation on Suicide Risk Factors of Patients With Mood Disorders

SuicideMood Disorders
Tianjin Anding Hospital300 enrolled1 locationNCT07523490
Recruiting
Not Applicable

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

Insulin ResistanceHyperinsulinismDepression+5 more
Colorado State University300 enrolled2 locationsNCT05543083
Recruiting

ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1

Depressed Mood
Salma Health, Inc.5,000 enrolled2 locationsNCT07528014
Recruiting

Study of Premenstrual Syndrome and Premenstrual Dysphoria

Mood Disorder
National Institute of Mental Health (NIMH)1,600 enrolled1 locationNCT00001177
Recruiting
Not Applicable

Preventing Maternal Mood, Anxiety, and Trauma Symptoms After Cesarean Delivery

Anxiety in PregnancyMood Disorder Due to Specified Medical Condition
University of Colorado, Denver80 enrolled1 locationNCT06949813
Recruiting

Psychotropic-Drug-induced QT Prolongation and ECG Monitoring in the Pediatric Population

Eating DisordersPsychotic DisorderMood Disorders in Children and Adolescents+1 more
Meyer Children's Hospital IRCCS100 enrolled6 locationsNCT06870006
Recruiting
Not Applicable

Transcutaneous Auricular Vagus Nerve Stimulation and Spirometry: Sham-Controlled Randomized Trial

Respiratory Function TestsBlood Pressure MonitoringVagus Nerve Stimulations+2 more
SEFA HAKTAN HATIK50 enrolled1 locationNCT07482930