RecruitingNot ApplicableNCT05546372

Endobiliary Radiofrequency Ablation for Malignant Biliary Obstruction Due to Perihilar Cholangiocarcinoma

Endobiliary Radiofrequency Ablation for Malignant Biliary Obstruction Due to Perihilar Cholangiocarcinoma: a Randomized Controlled Trial


Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Enrollment

98 participants

Start Date

Nov 9, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

A multicentre, parallel group, open label, randomized controlled trial comparing endobiliary RFA prior to metal stent placement with stent placement only in patients with inoperable perihilar cholangiocarcinoma.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying whether adding a heat-based treatment called endobiliary radiofrequency ablation (burning the tumor from inside the bile duct using a special probe) helps people with a type of inoperable bile duct cancer called perihilar cholangiocarcinoma live longer and maintain better drainage. **You may be eligible if...** - You are 18 or older - You have been diagnosed with perihilar cholangiocarcinoma (a cancer at the junction of the bile ducts near the liver) - Your cancer cannot be surgically removed due to spread or location - You need a stent placed to drain your bile duct **You may NOT be eligible if...** - You might be a candidate for surgery to remove the cancer - You are a candidate for liver transplant - Your life expectancy is less than 3 months - You have severe bleeding disorders - You have significant organ failure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEEndobiliary radiofrequency ablation (eRFA)

Intraductal radiofrequency ablation of tumor prior to stent placement

DEVICEuncovered self-expanding metal stent (uSEMS)

Intraductal placement of uncovered metal stent


Locations(1)

Amsterdam UMC location VUmc

Amsterdam, Netherlands

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