RecruitingPhase 1NCT05546723

LMY-920 for Treatment of Relapsed or Refractory Myeloma

LUMT1A22, Phase 1 Study of BAFF CAR T Cells (LMY-920) for Treatment of Relapsed or Refractory Myeloma (LMY-920-002)


Sponsor

Luminary Therapeutics

Enrollment

30 participants

Start Date

Mar 13, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Since CAR-T cell treatment of refractory myeloma has shown success, based on preclinical data, we posit that CAR-T cells expressing B-cell activating factor (BAFF) can become another strategy to treat refractory myeloma, even after relapse following BCMA targeting CAR-T cell treatment. This will be phase 1 study of BAFF ligand CAR-T cells in relapsed and refractory myeloma.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a new drug called LMY-920 in people with multiple myeloma (a cancer of plasma cells in the bone marrow) whose disease has come back or stopped responding to multiple previous treatments. **You may be eligible if...** - You are 18 years or older - You have multiple myeloma that has relapsed or not responded after at least 3 prior treatment regimens, including an immunomodulatory drug, a proteasome inhibitor, and an anti-CD38 antibody - Your disease is still measurable (detectable in blood, urine, or bone marrow tests) - You are in reasonably good physical condition (ECOG 0–2) **You may NOT be eligible if...** - Your myeloma has spread to your brain or spinal fluid - You have serious heart, liver, or kidney problems - You are pregnant or breastfeeding - You have an active serious infection - You have had a recent stem cell transplant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALAutologous CAR-T cell therapy expressing the BAFF-ligand.

LMY-920


Locations(1)

University Hospitals Seidman Cancer Center

Cleveland, Ohio, United States

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NCT05546723


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