RecruitingNCT05547633

Detection and Management of Sinusitis in a Single-center Prospective Cohort of Patients With Exudative AMD (SINE)

Sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Enrollment

200 participants

Start Date

Jan 20, 2023

Study Type

OBSERVATIONAL

Conditions

AMD

Summary

An inflammatory component associated with AMD has been highlighted by genetic associations of predisposition to AMD, as well as by the recently demonstrated link between AMD and periodontitis. Some patients followed at the Fondation Adolphe de Rothschild Hospital for wet AMD seemed to show an improvement of neovascular activity (less need for intravitreal injections of anti-VEGF) after treatment of their sinusitis. The investigators would therefore like to assess the link between AMD and sinusitis, an infection close to the site of AMD.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates the connection between sinusitis (sinus inflammation or infection) and exudative age-related macular degeneration (AMD) — a progressive eye condition that causes central vision loss. Researchers have observed a potential link between chronic sinus disease and AMD flare-ups. This study will identify how many AMD patients also have sinusitis, how it is managed, and whether treating sinusitis affects eye disease outcomes. You may be eligible if: - You are 18 years of age or older - You have been followed and treated for bilateral neovascular (wet) AMD for at least 2 years - You received at least 6 intravitreal injections in one eye in the past year - You have given consent to participate You may NOT be eligible if: - You have severe myopia (greater than 6 diopters) - You are already being treated for acute or chronic sinusitis - You have a history of central serous chorioretinopathy or diffuse retinal epitheliopathy - You are a minor, pregnant, breastfeeding, or under legal protection Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERsinusitis screening consultation

Questioning to look for suspicious anamnestic elements such as rhinorrhea, nasal obstruction, smell disorders, facial pain and clinical examination including nasofibroscopy. Patients with signs of sinusitis will be managed according to current recommendations (diagnostic imaging tests, medical treatment or even surgery if necessary).