RecruitingNCT05551416

The EpiGASTRIC/EDGAR Project: New Strategies for the Early Detection and Prevention of Gastric Cancer

Research and Development of New Strategies for the Early Detection and Prevention of Gastric Cancer in the Spanish Population: EpiGASTRIC/EDGAR Project.

Sponsor

EDUARDO ALBENIZ

Enrollment

1,200 participants

Start Date

Sep 9, 2021

Study Type

OBSERVATIONAL

Conditions

Gastric Cancer Gastric Neoplasms Gastric Lesion

Summary

This study is a multicenter, prospective cohort study, which are planned to enroll at least 600 patients who diagnosed the primary gastric cancer (GC); around 50 patients with premalignant gastric lesions (PGLs) and early gastric neoplasias (EGC) treated by endoscopy resection; and no less than 600 healthy normal cohort participants, for more than 18 months in the Spanish population. All participants who enrolled in this registry will be questioned by the life habits survey; and clinical data and biological samples of these participants were analyzed in order to look for new diagnostic tools. The aim of this study is to evaluate clinical, endoscopic and molecular approaches to identify individuals with high-risk of GC. Thus, it would be allow the adoption of preventive measures to reduce mortality through early detection and/or the reduction of its incidence.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is building a large patient database and collecting samples to better detect and prevent stomach cancer early. It involves people having stomach endoscopies (camera examinations), those with early stomach growths or lesions, and people already diagnosed with stomach cancer. **You may be eligible if...** - You are over 18 years old - You are having a diagnostic gastroscopy (stomach camera) for symptoms, OR - You have pre-cancerous stomach lesions being monitored or treated, OR - You have been diagnosed with stomach cancer (adenocarcinoma), OR - You are a healthy control without stomach problems or family history of stomach cancer **You may NOT be eligible if...** - You refuse to participate - You cannot legally or medically consent to the study - You have had previous stomach surgery or prior pre-cancerous stomach lesion diagnosis (for the first group) - You have a contraindication to endoscopy or biopsy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERIdentification of risk factors

Demographics, life habits and risk factors studies

OTHERCharacterization of premalignant gastric lesions

Identification and characterization of premalignant gastric lesions through high definition endoscopic study. Concordance between endoscopic and histological classifications

OTHERIdentification of biomarkers

Multiomic studies

OTHERIdentification of gastric cancer hereditary predisposition

Genomic studies for the identification of individuals with hereditary GC predisposition

Locations(15)

Hospital Comarcal de Inca

Palma de Mallorca, Balearic Islands, Spain

Hospital de Llevant

Porto Cristo, Balearic Islands, Spain

Hospital General de Granollers

Granollers, Barcelona, Spain

Consorci Sanitari de Terrassa

Terrassa, Barcelona, Spain

Hospital Santos Reyes

Aranda de Duero, Burgos, Spain

Hospital de Mérida

Mérida, Extremadura, Spain

Hospital Universitario de Ourense

Ourense, Galicia, Spain

Hospital Puerta de Hierro

Majadahonda, Madrid, Spain

Hospital Universitario de Navarra

Pamplona, Navarre, Spain

Hospital Universitario Central de Asturias

Oviedo, Principality of Asturias, Spain

Hospital Clínic de Barcelona

Barcelona, Spain

Hospital Universitario de Burgos

Burgos, Spain

Hospital Josep Trueta

Girona, Spain

Hospital Clínico Universitario Lozano Blesa

Zaragoza, Spain

Hospital Universitario Miguel Servet

Zaragoza, Spain

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NCT05551416

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