RecruitingNot ApplicableNCT05557864

Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease

Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease; Udall Project 2 Aims 1 & 2

Sponsor

University of Minnesota

Enrollment

24 participants

Start Date

Aug 25, 2016

Study Type

INTERVENTIONAL

Conditions

Parkinson's Disease

Summary

This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practice by providing a potential strategy to these medically intractable symptoms.

Eligibility

Min Age: 21 YearsMax Age: 89 Years

Inclusion Criteria3

diagnosis of idiopathic PD
have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)
Existing 7T brain imagery

Exclusion Criteria4

history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs
other significant neurological disorder
history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR)
post-operative complications or adverse effects

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