RecruitingNot ApplicableNCT05558345

Expression of Stress Markers During Meth Treatment (EXPRESS+)

Expression of Stress Markers in MSM Living With HIV Receiving Contingency Management for Methamphetamine Use Disorder

Sponsor

University of California, Los Angeles

Enrollment

55 participants

Start Date

Sep 1, 2022

Study Type

INTERVENTIONAL

Conditions

Substance-Related Disorders HIV

Summary

This is a non-randomized behavioral trial that aims to investigate whether changes in inflammatory and type I IFN expression coincide with changes in methamphetamine use and viral load over the course of 12 weeks in HIV-positive people assigned male at birth with and without methamphetamine use disorder.

Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study is examining biological stress markers (from blood and urine) in HIV-positive gay and bisexual men who use methamphetamine and are receiving behavioral treatment. The goal is to better understand how meth use and treatment affect the body's stress response. **You may be eligible if (for the treatment group):** - You were assigned male sex at birth and are 18–45 years old - You are HIV-positive and have a current antiretroviral prescription - You have been diagnosed with methamphetamine use disorder - You have had a recent positive urine test for methamphetamine - You are seeking treatment and can attend twice-weekly appointments - You have had sex with men in the past 12 months **You may NOT be eligible if:** - You identify as female - You have another active substance use disorder - You are enrolled in another substance use trial - You test positive for opioids, cocaine, or MDMA Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALContingency Management

A positive reinforcement behavioral treatment with escalating rewards for consecutive negative urine tests, starting at $10 and capped at a maximum of $40 per negative result.