RecruitingPhase 1Phase 2NCT05558904

An Investigational Scan (Me-4FDG PET/CT) for the Detection of Sodium-Glucose Transport for Early Diagnosis of Lung Cancer

Positron-Emission Tomography Detection of Sodium-Glucose Transport for Early Diagnosis of Lung Cancer

Sponsor

Jonsson Comprehensive Cancer Center

Enrollment

60 participants

Start Date

Jan 19, 2023

Study Type

INTERVENTIONAL

Conditions

Lung Adenocarcinoma

Summary

The phase I/II trial assess the safety and efficacy of a new positron emission tomography (PET) test for early diagnosis of lung cancer. This study uses PET and Me-4FDG new glucose tracer (alpha-methyl-4-deoxy-4-\[(18)F\]fluoro-D-glucopyranoside) designed specifically to determine glucose update into cells in the body. PET is a non-invasive imaging method used to detect cancer in patient. Me4FDG is a radioactive glucose tracer used in PET to locate cells in the body taking up glucose by SGLT2. SLGT2 is a sodium glucose transport protein that accumulates glucose in some cells, e.g. kidney cells and tumors. This study may help researcher determine how effective PET with ME4FDG tracer works in detecting lung cancer.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new PET scan using a tracer called Me-4FDG to detect the presence of a specific sugar transporter (called SGLT) in lung nodules. This may help identify whether a nodule is cancerous earlier and with less invasive testing. **You may be eligible if:** - You are 18 or older - You have a lung nodule of at least 1 cm seen on CT scan - Your lung nodule has been confirmed as adenocarcinoma (cancer) or is considered benign by your doctors **You may NOT be eligible if:** - You are pregnant - You have diabetes - You are currently taking SGLT2 inhibitors (such as empagliflozin, dapagliflozin) or metformin Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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