Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 Targeted

This study is testing whether statin medications (commonly used for cholesterol) can protect the heart from damage caused by HER2-targeted therapy (a type of breast cancer treatment that can sometimes weaken the heart). Researchers want to see if statins reduce the risk of heart problems during breast cancer treatment. **You may be eligible if:** - You are a woman 18 or older diagnosed with Stage I–III breast cancer - Your cancer is HER2-positive and you are scheduled to receive HER2-targeted therapy - Your heart function is normal (ejection fraction of at least 50%) - You have not previously received HER2-targeted therapy or anthracycline chemotherapy - Your blood counts, liver, and kidney function are adequate **You may NOT be eligible if:** - You have Stage IV (metastatic) breast cancer - You are currently taking statin medications - You have uncontrolled high blood pressure - You have active liver disease - You are pregnant Talk to your doctor to see if this trial is right for you.